Cancer     
  Mission: To divide and conquer  
    Introduction

This set of articles examines cancer, its causes and development, the range of treatments that are available, their potential risks, and their likely benefits.

If you’re interested in reading further, then start with the “Action Plan” in the “Overview” that follows; if not, then good luck.

This topic is divided into the following sections:

Overview

The Key to Curing Cancer

Alternative Treatments

Big-Pharma Treatments

Cancer Types and Causes

Biochemistry and Diagnostics

Apologia: This topic is very much an “opus in profectus” at present: links coloured red go “somewhere”; those coloured black will, hopefully, do likewise at some point in the future – but for the present they just amount to wishful thinking on my part.

    Overview

In this section, we’ll review the steps involved in preparing a personalized cancer action plan; we’ll look at the difficulties involved in getting information on cancer that is both understandable and reliable; we’ll examine the issues involved in selecting the best range of cancer treatments (one that embraces both big-pharma medicine and alternative medicine); and we’ll consider how to go about building a team of competent health-care practitioners (including a list of questions and answers that can be used to assess the competence and areas of expertise of candidate health-care practitioners):

Introduction

How to Find Information on Cancer

How To Find The Best Cancer Treatments

How To Find the Best Health-Care Practitioners

*Practitioner Selection – Your Life In Their Hands!

*Questions & Answers – Is Your Doctor Competent?

    Systematic Treatment Selection

Most health-care practitioners don’t recommend the best set of cancer treatments, be they oncologists or alternative medicine practitioners. In this section, we’ll examine how a competent health-care practitioner goes about selecting a range of cancer treatments, and, more importantly, how you can ensure that the health-care practitioners that you select possess the requisite level of expertise:

Overview

Adhesion and Extracellular Matrix Modulators

*Endothelial Leukocyte Adhesion Molecule-1 (ELAM-1 / E-selectin) Inhibitors

*Intercellular Adhesion Molecule-1 (ICAM-1) Inhibitors

*Urokinase-Type Plasminogen Activator (uPA) Inhibitors

*Vascular Cell Adhesion Molecule-1 (VCAM-1) Inhibitors

*More to come ...

Apoptotic Modulators

*B-Cell Lymphoma-2 (Bcl-2) Inhibitors

*B-Cell Lymphoma-Extra Large (Bcl-xL) Inhibitors

*Cellular Inhibitor of Apoptosis Protein-1 (cIAP1 / BIRC2) Inhibitors

*DNA Fragmentation Factor 40-kDa Subunit (DFF40) Promoters

*Heat Shock Protein-70 (Hsp70) Inhibitors

*Tumour Suppressor p53 (p53) Promoters

*More to come ...

Cell Cycle Modulators

*Cyclin-D1 Inhibitors

*More to come ...

Cytokines

*Interleukin-1 (IL-1) Inhibitors

*Interleukin-2 (IL-2) Promoters

*Interleukin-6 (IL-6) Inhibitors

*Interleukin-8 (IL-8) Inhibitors

*Interleukin-12 (IL-12) Promoters

*Macrophage Inflammatory Protein (MIP) Inhibitors

*Macrophage Migration Inhibitory Factor (MIF / MMIF) Inhibitors

*Monocyte Chemoattractant Protein-1 (MCP-1 / CCL2) Inhibitors

*Tumour Necrosis Factor Alpha (TNFα) Inhibitors

*More to come ...

Enzymes

*Arylamine N-acetyltransferase-2 (NAT2) Inhibitors

*Ca2+-ATPase-2 Inhibitors

*Cyclooxygenase-2 (COX-2) Inhibitors

*DNA Polymerase Inhibitors

*Farnesyltransferase (FTase) Inhibitors

*Glutamate Cysteine Ligase (GCL) Modulators

*Glutathione S-Transferase (GST) Modulators

*Heme Oxygenase-1 (HO-1) Inhibitors

*Inducible Nitric Oxide Synthase (iNOS) Inhibitors

*Lipoxygenase Inhibitors

*Matrix Metalloproteinase (MMP) Inhibitors

*NAD(P)H Quinone Oxidoreductase (NQO1) Inhibitors

*Ornithine Decarboxylase (ODC) Inhibitors

*Phospholipase D (PLD) Inhibitors

*Src Homology-2 Domain-Containing Tyrosine Phosphatase-2 (SHP2) Promoters

*Stearoyl-CoA Desaturase (SCD) Inhibitors

*Telomerase Inhibitors

*Tissue Inhibitor of Metalloproteinase-3 (TIMP3) Promoters

*More to come ...

Growth Factors

*Connective Tissue Growth Factor (CTGF) Modulators

*Epidermal Growth Factor (EGF) Inhibitors

*Fibroblast Growth Factor (FGF) Inhibitors

*Hepatocyte Growth Factor (HGF) Inhibitors

*Platelet-Derived Growth Factor (PDGF) Inhibitors

*Tissue Factor (TF) Inhibitors

*Transforming Growth Factor Beta-1 (TGF-β1) Modulators

*Vascular Endothelial Growth Factor (VEGF) Inhibitors

*More to come ...

Kinases

*Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) Inhibitors

*EGF Receptor Tyrosine Kinase Inhibitors

*Extracellular Signal–Regulated Kinase (ERK / MAPK) Inhibitors

*Focal Adhesion Kinase (FAK / PTK2) Inhibitors

*Interleukin-1 Receptor-Associated Kinase (IRAK) Inhibitors

*Janus Kinase (JAK) Inhibitors

*Phosphorylase Kinase (PhK) Inhibitors

*Protein Kinase A (PKA) Inhibitors

*Protein Kinase B (PKB) Inhibitors

*Protein Kinase C (PKC) Inhibitors

*Proto-Oncogene Tyrosine-Protein Kinase Src (pp60c-src / c-Src) Inhibitors

*More to come ...

Receptors

*Androgen Receptor (AR) Inhibitors

*Aryl Hydrocarbon Receptor (AhR) Inhibitors

*Chemokine Receptor Type-4 (CXCR4) Inhibitors

*Death Receptor-5 (DR5 / TRAILR2) Modulators

*EGF Receptor Inhibitors

*Endothelial Protein C Receptor (EPCR) inhibitors

*Estrogen Receptor Alpha (ERα) Modulators

*FAS Receptor (FasR) Promoter

*Histamine H2 Receptor Inhibitors

*Human Epidermal Growth Factor Receptor (HER2 / neu) Inhibitors

*Inositol 1,4,5-Trisphosphate Receptor (IP3R) Inhibitors

*Integrin Receptor Inhibitors

*Interleukin-8 Receptor (IL8R1&2) Inhibitors

*Low-Density Lipoprotein Receptor (LDL-R) Inhibitors

*More to come ...

Transcription Factors

*Activator Protein-1 (AP-1) Inhibitors

*β-Catenin Inhibitors

*cAMP-Response Element Binding Protein (CREB / CBP) Inhibitors

*Early Growth Response Protein-1 (EGR-1) Modulators

*Electrophile Response Element (EpRE / ARE) Modulators

*Hypoxia Inducible Factor-1 (HIF-1) Inhibitors

*Notch-1 Modulators

*Nuclear Factor-Erythroid 2-Related Factor-2 (Nrf2) Modulators

*Nuclear Factor-kappa B (NFκB) Inhibitors

*Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) Promoters

*Signal Transducers and Activators of Transcription-3 (STAT3) Inhibitors

*Signal Transducers and Activators of Transcription-5 (STAT5) Inhibitors

*Wilms’ Tumour – Tumour Suppressor Gene-1 (WT1) Inhibitors

*More to come ...

Transporters

*Multidrug Resistance Protein-1 (MRP1 / ABCC1) Inhibitors

*More to come ...

    Cancer Diets

In this section, we’ll examine how your diet can increase, or decrease, your chances of surviving cancer:

*The Cure-You-And-Kill-You Dilemma!

*Don’t Feed Your Cancer!

*More Fat Equals More Cancer?

*Calorie Restriction (CRON)

*High or Low Carbohydrate Diet?

*Alkaline Diet

*Ketogenic Diet

*More to come ...

    Breathing Techniques

In this section, we’ll examine how various breathing and oxygen-therapy techniques can be used to curative and palliative effect in the treatment of cancer:

*Yoga Pranayama

*Buteyko Breathing

*Breath Holding – A Promoter of Cancer?

*Hyperbaric Oxygen Therapy (HBOT)

*More to come ...

    Nutritional and Herbal Treatments

In this section, we’ll examine those low-risk alternative treatments that take the form of nutritional or herbal supplements. These treatments are inexpensive, can be purchased online, and can be administered at home without the need to attend a clinic. The early adoption of these treatments – as soon as cancer is suspected and in the months before any big-pharma treatments can be initiated – may be the most important factor in ensuring your long-term survival. It’s very important to bear in mind that for the purposes of effective cancer treatment supplements must contain appropriate concentrations of the key ingredients, must be in appropriate biochemical forms in order to maximize bioavailability, and must contain doses that are much higher than those recommended for cancer prevention or for general health purposes:

*Acetyl-L-Carnitine

*Aloe

*Alpha-Lipoic Acid

*Apigenin

*Arabinoxylan (Enzymatically Modified Rice Bran)

*Astaxanthin

*Astragalus

*Berberine

*Beta-Carotene

*Black Tea Polyphenols

*Blueberry Polyphenols

*Canthaxanthin

*Chlorogenic Acid

*Chrysin

*Conjugated Linoleic Acid

*CoQ10

*Curcumin

*DHA

*Diallyl Disulfide

*Dietary Fibre

*D-Limonene

*EGCG

*Enterolactones (Lignans)

*EPA

*Feverfew (Tanacetum Parthenium)

*Gamma-Tocotrienol

*Garlic (Allium Sativum)

*Genistein

*Ginger (Zingilber Officinalis)

*Glutamine

*Grape Seed Proanthocyanidins

*Inositol Hexaphosphate (IP-6)

*Lactoferrin

*L-Arginine

*L-Carnitine

*Lycopene

*Melatonin

*Modified Citrus Pectin

*N-Acetyl Cysteine

*Panax Ginseng

*Perillyl Alcohol

*Pomegranate

*PSK (Coriolus Versicolor)

*Pterostilbene

*Pyridoxal 5-Phosphate

*Quercetin

*Reishi

*Resveratrol

*R-Lipoic Acid

*Selenium

*Silymarin

*Soy Isoflavones

*Sulforaphane

*Theanine

*Vitamin A

*Vitamin C

*Vitamin D

*Vitamin K1

*Vitamin K2-M4

*Vitamin K2-M7

*Zinc

*More to come ...

    Off-Label Drugs

In this section, we’ll examine the off-label drugs that are used to treat cancer (drugs that are designated for the treatment of other medical conditions but which are used off-label by some health-care practitioners in the treatment of cancer):

*Aspirin

*Celebrex

*Celecoxib

*Chloroquine

*Cimetidine

*Clodronate

*Dimethyl Sulfoxide (DMSO)

*Lodine XL

*Metformin

*Mevacor

*Pravachol

*Rofecoxib

*Tagamet

*Zileuton

*Zocor

*More to come ...

    Supervisory Curative Alternative Treatments

In this section, we’ll examine some supervisory alternative treatments, typically those that involve intravenous infusions, special equipment, or medical supervision:

*Alpha-Lipoic Acid / Low-Dose Naltrexone (ALA-N)

*Insulin Potentiation Therapy (IPT)

*Laetrile

*Oxidative Stress Therapy

*Pancreatic Enzyme Therapy

*Ukrain

*More to come ...

    Supportive Alternative Treatments

In this section, we’ll examine supportive alternative treatments, treatments that are used to help remedy the damage caused by big-pharma treatments and to reduce physical pain and emotional discomfort:

*Acupuncture

*Meditation

*Yoga

*More to come ...

    Alternative Cancer Protocols

In this section, we’ll examine alternative cancer protocols, each of which consists of a collection of curative and supportive alternative treatments – and which is often the life work of a particular alternative medicine practitioner:

*Contreras Cancer Care

*Gerson Therapy

*Gonzalez Protocol

*More to come ...

    Surgery

In this section, we’ll examine surgery. It’s usually the preferred, first treatment of choice, but, beware, for what your surgeon probably won’t tell you is that surgery promotes metastatic cancer. We’ll discuss what you need to do before going under the knife, as well as what’s required to minimize the surgery-induced, cancer-promoting effects of enhanced cell adhesion, immune suppression, and inflammation:

Introduction

*Overview

Surgery Enhancement

*Differential Anaesthesia

*Laparoscopic Surgery

*Perioperative Radiotherapy and Chemotherapy

*More to come ...

Side Effects

*Enhanced Cell Adhesion

*Immune Suppression

*Inflammation

*Surgery-Induced Metastasis

*More to come ...

    Radiotherapy

In this section, we’ll examine radiotherapy. It’s usually the preferred, second treatment of choice, but it comes with a long list of side effects:

Introduction

*Overview

Radiotherapy Enhancement

*Cancer Cell Sensitization

*More to come ...

Side Effects

*Alopecia

*Cachexia

*Fibrosis

*Gastrointestinal Mucositis

*Hypersensitivity Reactions

*Lymphedema

*Nausea and Vomiting

*Necrosis

*Oral Mucositis

*Radiation Hepatitis

*Radiation-Induced Heart Damage

*Radiation-Induced Peripheral Neuropathy

*Radiation Nephropathy

*Radiation Pneumonitis

*Secondary Cancers

*Sexual Dysfunction

*More to come ...

    Chemotherapy

In this section, we’ll examine chemotherapy – and why the type you’re almost certain to be offered is the type least likely to cure your cancer:

Introduction

*Overview

Chemotherapy Enhancement

*Angiogenesis Inhibitors

*COX-2 Inhibitors

*Immune System Enhancement

*Ras Suppression

*Signal Transduction Inhibitors

*The Antioxidant Debate

*More to come ...

Types of Chemotherapy

*Maximum Tolerated Dose Chemotherapy

*Dose-Dense Chemotherapy

*Metronomic Chemotherapy

*Adaptive Chemotherapy

Side Effects

*How to Eliminate Side Effects

*Anaemia

*Appetite Suppression

*Cardiotoxicity

*Extravasation (Chemotherapy)

*Heptotoxicity

*Hypersensitivity Reactions

*Nausea and Vomiting

*Nephrotoxicity

*Neutropenia

*Osteoporosis

*Thrombocytopenia

*More to come ...

    Biological Therapies

In this section, we’ll examine the big-pharma biological therapies that target specific cancer biomarkers and signalling pathways:

*Apatinib

*Bortezomib

*Crizotinib

*Dabrafenib

*Dasatinib

*Erlotinib

*Everolimus

*Gefitinib

*Gossypol

*Imatinib

*Iniparib

*Lapatinib

*LGX818

*MEK162

*Navitoclax

*Nilotinib

*PD-0332991

*Perifosine

*Salinomycin

*Sorafenib

*Sunitinib

*Tamoxifen

*Temsirolimus

*Tofacitinib

*Trametinib

*Vemurafenib

*Vintafolide

*More to come ...

    Immunological Therapies

In this section, we’ll examine therapies that make use of the immune system to target cancer:

*Adoptive T-Cell Transfer Therapy

*Bacillus Calmette-Guérin (BCG)

*Cancer Vaccines

*Monoclonal Antibodies

*Oncolytic Virus Therapy

*More to come ...

    Miscellaneous Curative Big-Pharma Treatments

In this section, we’ll examine miscellaneous curative big-pharma treatments:

*Gene Therapy

*Photodynamic Therapy (PDT)

*Radiofrequency Ablation (RFA)

*More to come ...

    Supportive Big-Pharma Treatments

In this section, we’ll examine supportive big-pharma treatments, treatments that are used to help remedy the damage caused by curative big-pharma treatments and by certain cancers:

Anaemia

*Blood Transfusion

*Erythropoietin (EPO)

*More to come ...

Neutropenia

*Granulocyte Colony-Stimulating Factor (G-CSF)

*More to come ...

Thrombocytopenia

*Platelet Transfusion

*Platelet Growth Factors

*More to come ...

Hyperviscosity Syndrome

*Plasmapheresis

*More to come ...

Osteoporosis

*Bisphosphonates

*More to come ...

Nausea / Hypersensitivity Reactions / Appetite Suppression

*Corticosteroids

*More to come ...

Radiation Tissue Damage

*Hyperbaric Oxygen Therapy (HBOT)

*More to come ...

Ureteral Obstruction

*Nephrostomy

*More to come ...

    Cancer Types

In this section, we’ll examine a range of issues that are specific to particular types of cancer:

*Brain Cancer

*Breast Cancer

*Cervical Cancer

*Colorectal Cancer

*Endometrial Cancer

*Leukaemia

*Liver Cancer

*Melanoma

*Ovarian Cancer

*Pancreatic Cancer

*Prostate Cancer

*More to come ...

    Cancer Causes

In this section, we’ll examine the relative impact that lifestyle, environmental, and genetic factors have on carcinogenesis. An effort to favourably alter these factors can be initiated at any time, irrespective of whether or not you have cancer:

*Overview

*Lifestyle Factors

*Environmental Factors

*Genetic Factors

*More to come ...

    Development Steps

In this section, we’ll examine the development steps through which cancer progresses:

*Cell Transformation

*Cell Proliferation

*Angiogenesis

*Metastasis (Intravasation)

*Metastasis (Extravasation)

*More to come ...

    Cellular Processes

In this section, we’ll examine the cellular processes that are down- or upregulated by cancer:

*Apoptosis

*Cell Cycle Arrest

*Differentiation

*DNA Repair

*Glycolysis

*Immortalization and Senescence

*Immune System Activation

*Inflammation

*Mitochondrial Dysfunction

*ROS Generation

*More to come ...

    Molecular and Functional Profiling

In this section, we’ll examine how cancer treatments can be individualized – for example, by identifying the chemotherapy drugs to which your tumour is both sensitive and resistant you might increase your survival by up to 400%:

*Overview

*Genomic Testing / Molecular Profiling

*Ex-Vivo Testing / Functional Profiling

*Circulating Tumour Cells (CTC) Testing

*More to come ...